Novel In Silico and In Vivo Insights of Flavonoids as Anti-Diabetic and Anti-Oxidant in Rodent Models

Insulin sensitivity is a symptom of diabetes, which caused by insulin resistance, decreasing production and ultimately pancreatic cancer. The current study focused on the anti-diabetic antioxidant properties Chrysanthemum indicum flower extract to scientifically validate claim in silico docking studies natural compounds present for their respective sites against selected proteins. Pharmacological evaluations were done using 200 400 mg/kg body weight extract. Upon treatment with methanolic at weight, glibenclamide 0.5 significant reduction blood glucose levels was observed. screened reducing power assay hydrogen peroxide scavenging its anti-oxidant potential results compared standard ascorbic acid. In both assays, findings clearly demonstrated extract's ability scavenge free radicals. Docking performed such as epigallactocatechin, quercetin, kaempferol, apigenin, myrcetin, rutin, luteolin drug protein data bank ID: 1VA5, 1Z2C, 5WUA Mcule software. statistical verification model evaluated PROCHEK; structure program relies Ramachandran plot determines quality predicted structures. revealed that epigallactocatechin rutin had shown highest glide scores indicates stronger receptor-ligand binding affinity among various phytochemical constituents this might be possible mechanism showed antidiabetic activities. From above it concluded possess activity.